Our Platform

Most mucosal surfaces that interface with the outside world, such as the surface of the lungs, are lined with fluid. The fluid that lines the surface of the lung is critical for host defense and overall lung health.

The lung lining fluid contains thousands of proteins and peptides that drive normal functioning of the lung. For example, short palate and nasal epithelial clone 1 (SPLUNC1) is a secreted protein that is highly abundant in the lung lining fluid and regulates fluid homeostasis and inflammation.

Decreased SPLUNC1 levels have been shown to be associated with increased disease severity in multiple chronic lung diseases such as cystic fibrosis (CF), non-CF bronchiectasis, chronic obstructive pulmonary disease and asthma.

In creating the “Lung Peptidome” platform, Eldec identified, sequenced and synthesized all detectable peptides secreted by the lung into the lung lining fluid. These peptides have been assessed for potential pharmacologic activity, such as inhibition of inflammation or cell growth.

Peptides of interest are further optimized to improve potency, stability and solubility and make then better drug candidates.